Luckily, every Roku device has an easy way to reestablish the connection. And if your remote control won't interact with your Roku, then your streaming gadget is basically inoperable. The trouble with the Roku remote is that a variety of factors can disrupt this pairing, from shaky Wi-Fi to a factory reset. This way, you don't need your TV remote, as the Roku remote can control volume and power settings, too (If only it controlled your input device, like the Chromecast with Google TV's remote). In fact, newer models will even pair your remote control directly with your TV.
When you first set up a Roku player, it should automatically pair with your remote control. Since you already tried replacing your batteries or re-charging as I suggested above, the next most common cause of Roku remote woes is the pairing malfunction.